Nasal corticosteroid sprays and antihistamines

Mometasone furoate increased chromosomal aberrations in an in vitro Chinese hamster ovary-cell assay, but did not increase chromosomal aberrations in an in vitro Chinese hamster lung cell assay. Mometasone furoate was not mutagenic in the Ames test or mouse- lymphoma assay, and was not clastogenic in an in vivo mouse micronucleus assay and a rat bone marrow chromosomal aberration assay or a mouse male germ -cell chromosomal aberration assay. Mometasone furoate also did not induce unscheduled DNA synthesis in vivo in rat hepatocytes.

Corticosteroids taken by mouth or injection have been shown to slow or stop growth in children and cause reduced adrenal gland function. If corticosteroids are medically necessary to control nasal problems in a child, nasal corticosteroids are generally considered to be safer than corticosteroids taken by mouth or injection. Prolonged or high-dose use of nasal corticosteroids may potentially affect growth; although, most nasal corticosteroids have not been shown to affect growth. Also, use of most nasal corticosteroids may allow some children to stop using or decrease the amount of corticosteroids taken by mouth or injection.

Azelastine hydrochloride displayed no sensitising potential in the guinea pig. Azelastine demonstrated no genotoxic potential in a battery of in vitro and in vivo tests, nor any carcinogenic potential in rats or mice. In male and female rats, azelastine at oral doses greater than 3 mg/kg/day caused a dose-related decrease in the fertility index; no substance-related alterations were found in the reproductive organs of males or females during chronic toxicity studies, however, embryotoxic and teratogenic effects in rats, mice and rabbits occurred only at maternal toxic doses (for example, skeletal malformations were observed in rats and mice at doses of mg/kg/day).

Nasal corticosteroid sprays and antihistamines

nasal corticosteroid sprays and antihistamines

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