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In summary, the excitement around myostatin inhibition will only continue to grow as the popularity of this approach takes off. Not only will we see the ceiling of human performance raised to a new height, but we are already seeing staggering improvements in quality of life. We may even one day soon see this approach curing disease and dramatically lengthening our existence here on earth. Certainly if/when myostatin blocking drugs ever arrive, the abuses will invariably happen. But nothing can stop the juggernaut of the natural myostatin-inhibiting evolution that is just now in its infancy.
Due to myostatin’s ability to inhibit muscle growth, it can indirectly inhibit bone formation by decreasing the load on the bone.   It has a direct signalling effect on bone formation  as well as degradation.   Knockdown of myostatin has been shown to reduce formation of osteoclasts (multinucleated cells responsible for the breakdown of bone tissue) in mice modeling rheumatoid arthritis.  Arthritis is an autoimmune disorder that, among other effects, leads to the degradation of the bone tissue in affected joints. Myostatin has not, however, been shown to be solely sufficient for the formation of mature osteoclasts from macrophages, only an enhancer.