Sunless tanning preparations may be used to darken the vitiligo a more acceptable color. These will cover small areas of vitiligo well. Micropigmentation (tattooing) is rarely recommended. It works best for the lip area, particularly in people with dark skin; however, it is difficult to perfectly match the skin, and tends to look worse over time. For loss of pigment over more than half of the exposed areas of the body, depigmentation therapy can be considered. This is the permanent (or nearly permanent) bleaching out of all pigmentation. The remaining skin will be an even white color, which can then be covered with the cosmetics.
Hyper-pigmentation and congenital pigment spots. Moles, or birthmarks, represent a congenital abnormality of development of the skin. They have the appearance of small or large spots, not raised, and sometimes slightly or even considerably elevated above the surface of the skin; sometimes they resemble warts, are often covered with hair. Color pigmented birthmarks can vary from light brown to dark brown, brown and black-brown with a variety of shades. Birthmarks are not always detected immediately after birth – they can appear during puberty and even later and there are no changes throughout life. However, they may slowly increase.
In October 1992, a scientific report was published of successfully transplanting melanocytes to vitiligo affected areas, effectively re-pigmenting the region.  The procedure involved taking a thin layer of pigmented skin from the patient's gluteal region. Melanocytes were then separated out to a cellular suspension that was expanded in culture. The area to be treated was then denuded with a dermabrader and the melanocytes graft applied. Between 70 and 85 percent of patients experienced nearly complete repigmentation of their skin. The longevity of the repigmentation differed from person to person.  By now, several transplantation techniques have been developed, including transplantation of melanocyte precursors derived from hair follicles. Transplantation procedures are frequently used to treat segmental vitiligo which is poorly responsive to other types of treatment. In non-segmental vitiligo, success is achieved when treating patches that are not expanding (so called stable vitiligo).